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WIREs Syst Biol Med
Impact Factor: 4.192
Wiley Interdisciplinary Reviews:
WIREs Systems Biology and Medicine
Volume 10 Issue 4 (July 2018)
Page 0 - 0

Advanced Review

PharmGKB: A worldwide resource for pharmacogenomic information
Published Online: Feb 23 2018
DOI: 10.1002/wsbm.1417
The PharmGKB Knowledge Pyramid. A visual representation of the information available at www.pharmgkb.org and the research by the PharmGKB team. The PharmGKB Knowledge Pyramid provides users with a visualization of the different types of information found in our knowledge base and, how this information is acquired and integrated together—from the accumulation of gene‐drug knowledge at the bottom of the pyramid, to the implementation of pharmacogenomics (PGx) in the clinic at the top. (PharmGKB is one of the preeminent worldwide resources for pharmacogenomic information. It is freely available to all users, and provides an interface that is easy to use for researchers, clinicians, and everyday citizens.)
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Focus Articles

Multiscale systems biology of trauma‐induced coagulopathy
Published Online: Feb 27 2018
DOI: 10.1002/wsbm.1418
The global hemodynamics model is typically represented as a closed‐loop hydraulic circuit that includes lumped, zero‐dimensional, descriptions of the various components of the body. Bleeding can be included in these models by connecting the circuit to atmospheric pressure through a “resistance‐to‐hemorrhage” resistor, as is done in the Reisner–Heldt model (Reisner & Heldt, 2013). At this scale, cardiovascular output is primarily modulated by the baroreflex and transcapillary fluid shifts. At the tissue level scale (cm), vasculature branching networks are constructed to match physiological conditions before a wound occurs. Once severed, boundary conditions to model blood flow may include inlet pressure/flow conditions and an outlet pressure specification (typically atmospheric pressure). At this scale, modeling efforts should include variable resistance to flow (changing vessel diameter) to divert flow away from the site of injury. At the vessel scale (mm), parabolic flow is assumed in the healthy vessel. In the event of trauma, pressure and flow specifications are both possible, which are set by the global hemodynamic model, with the extrinsic coagulation pathway (tissue factor) being the predominant trigger for maintaining hemostasis. Transfusion, vasopressors, and clotting modulators are standard treatment options.
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Systems analysis of dilated cardiomyopathy in the next generation sequencing era
Published Online: Feb 27 2018
DOI: 10.1002/wsbm.1419
Systems analysis approach integrates various levels of information originating from cardiac tissue and translates knowledge into clinics.
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Chromatin modifications in metabolic disease: Potential mediators of long‐term disease risk
Published Online: Jan 25 2018
DOI: 10.1002/wsbm.1416
Modifications to chromatin are associated with the development of metabolic diseases, including type 2 diabetes and obesity. There is evidence that these chromatin modifications can lead to long‐term disease risk and increase disease risk for offspring.
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