Volume 10, Issue 5 - WIREs WIREs Systems Biology and Medicine

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WIREs Syst Biol Med

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WIREs Systems Biology and Medicine

Volume 10 Issue 5 (September 2018)

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Overviews

Mechanisms of Wnt signaling and control

Stephanie Grainger, Karl Willert

Published Online: Mar 30 2018

DOI: 10.1002/wsbm.1422

Schematic diagram of WNT, FZD and LRP oligomerization; the beginning of the WNT signal. On the left, the WNT signal is off. On the right, the WNT signal is on.

Abstract Full article on Wiley Online Library: HTML | PDF

Systems approaches to optimizing deep brain stimulation therapies in Parkinson’s disease

Sabato Santaniello, John T. Gale, Sridevi V. Sarma

Published Online: Mar 20 2018

DOI: 10.1002/wsbm.1421

A systems theoretical approach to DBS from individual neuron models to control approaches to personalize the therapy.

Abstract Full article on Wiley Online Library: HTML | PDF

Advanced Review

Diversification of transcription factor–DNA interactions and the evolution of gene regulatory networks

Julia M. Rogers, Martha L. Bulyk

Published Online: Apr 25 2018

DOI: 10.1002/wsbm.1423

Transcription factor–DNA interactions can change by a variety of mechanisms in evolution, leading to changes in gene regulatory networks.

Abstract Full article on Wiley Online Library: HTML | PDF

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