Published Online: May 28 2019
DOI: 10.1002/wsbm.1447
How to cite this WIREs title:
WIREs Syst Biol Med
WIREs Syst Biol Med
Impact Factor: 4.275
Wiley Interdisciplinary Reviews:
WIREs Systems Biology and Medicine
WIREs Systems Biology and Medicine
Volume 11 Issue 5
(September 2019)
Page 0 - 0
Overview
Focus Articles
Published Online: Apr 29 2019
DOI: 10.1002/wsbm.1450
Advances in mass spectrometry recently offered circadian proteomics new perspectives, that is, the possibilities of performing large scale proteomic studies at the cellular and subcellular level and of studying temporal dynamics of posttranslational modifications.
Published Online: Apr 23 2019
DOI: 10.1002/wsbm.1449
Microglia are cells of the immune system that reside in the brain and that have been implicated in various brain diseases. Recent studies on the contribution of their repertoire of enhancer regulatory elements demonstrate that the identity of these cells critically depends on complex molecular interactions that connect signaling factors present in the brain microenvironment to the microglial chromatin architecture on a genome‐wide scale.
Published Online: Mar 18 2019
DOI: 10.1002/wsbm.1448
Calcium signaling mechanisms in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs). VDCC: voltage‐dependent calcium channels or CaV; BK: large conductance calcium‐activated potassium channel; RyR: ryanodine receptor; SERCA: sarco/endoplasmic reticulum calcium ATPase; CaM: calmodulin; ER: endoplasmic reticulum; IP3R: IP3 receptor; MLCK: myosin light chain kinase; DAG: diacylglycerol; PKC: protein kinase C; PLC: phospholipase C; GqPCR: Gq protein coupled receptor; TRP: transient receptor potential channel; P2X1R: purinergic P2X1 receptor; MEP: myoendothelial projection; IK/SK: calcium‐activated intermediate and small conductance potassium channels; MEGJ: myoendothelial gap junction.