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WIREs Syst Biol Med
Impact Factor: 4.275
Wiley Interdisciplinary Reviews:
WIREs Systems Biology and Medicine
Volume 11 Issue 6 (November 2019)
Page 0 - 0

Advanced Reviews

Stochastic simulation algorithms for computational systems biology: Exact, approximate, and hybrid methods
Published Online: Jul 01 2019
DOI: 10.1002/wsbm.1459
A graphical representation of the simulation algorithms introduced in the review. Starting from a common root node representing a generic stochastic simulation algorithm, the methodologies differentiate in terms of accuracy and runtime according to exact and approximate methods. We depict with rectangles the algorithm classes and with circles the specific methods. Hybrid methods are here represented as a part of the approximate methods, however, they are often referred as a class of simulation algorithms itself. In the diagram, the τ‐leaping and the chemical Langevin methods are connected since, following the Gillespie's approach, the latter can be derived as an approximation of the former. Analogously, the deterministic methods are connected with the chemical Langevin method. Deterministic methods are indicated with dashed lines since they are not described in detail in this review.
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Multiscale modeling of the neuromuscular system: Coupling neurophysiology and skeletal muscle mechanics
Published Online: Jun 24 2019
DOI: 10.1002/wsbm.1457
The neuromuscular pathway of movement: the figure illustrates the simplified flow of neuromuscular interaction with its three essential components: (a) neural drive comprises projection from supraspinal centers (solid lines), afferent feedbacks (dashed lines) from two exemplary proprioceptive sensory cells, that is, muscle spindle and Golgi tendon organs (Golgi TO) on spinal motor neurons (alpha‐MN) and gamma motor neurons (gamma‐MNs). The scheme includes ascending branches of sensory afferents which contribute primary somatosensory cortex (orange shade on the brain figure). (b) The excitation‐contraction part shows excitation of extrafusal and intrafusal muscle fibers by alpha‐MN and gamma‐MNs, respectively. (c) The multidirectional joint torque is depicted as a resultant of the neuromuscular interaction.
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