The cover image is based on the Advanced Review Skeletal Muscle: A Review of Molecular Structure and Function, In Health and Disease, by Kavitha Mukund and Shankar Subramaniam. https://doi.org/10.1002/wsbm.1462

Pluripotent stem cells have the ability to unlimitedly self‐renew and differentiate to any somatic cell lineage. Advances in genetic perturbation methods are enabling comprehensive interrogation of pluripotency and differentiation through large‐scale genetic screens. Findings from such screening efforts will have broad implications for developmental biology, stem cell and regenerative medicine.

The current review focuses on molecular structure and function of the various components of muscle physiology. Within each component, we highlight the necessary molecular mechanisms and cross‐talk critical for defining the state of muscle health. We also highlight instances of aberrant molecular mechanisms underlying disease.

Magnetic Resonance Imaging (MRI) is a versatile method for the non‐invasive imaging of anatomy, physiology, and function. The brain images shown here reflect measures of anatomical structure (top row), structural connectivity (left middle row), functional activity (right middle row), mean diffusivity (left bottom row), and cerebral blood flow (right bottom row).