Madeleine Fosslie, Adeel Manaf, Mads Lerdrup, Klaus Hansen, Gregor D. Gilfillan, John Arne Dahl
Published Online: Sep 03 2019
DOI: 10.1002/wsbm.1465
Standard native (N)ChIP and cross‐linking (X)ChIP protocols are not suitable for low cell number samples. This article reviews advances central to downscaling of the ChIP method, important examples of biological insights revealed by small‐scale ChIP‐seq experiments, and delineates important considerations when performing ChIP‐seq with limited amounts of material.
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Kavitha Mukund, Shankar Subramaniam
Published Online: Aug 13 2019
DOI: 10.1002/wsbm.1462
The current review focuses on molecular structure and function of the various components of muscle physiology. Within each component, we highlight the necessary molecular mechanisms and cross‐talk critical for defining the state of muscle health. We also highlight instances of aberrant molecular mechanisms underlying disease.
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