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WIREs Syst Biol Med
Impact Factor: 4.275
Wiley Interdisciplinary Reviews:
WIREs Systems Biology and Medicine
Volume 12 Issue 3 (May 2020)
Page 0 - 0

Advanced Reviews

Liver gene regulatory networks: Contributing factors to nonalcoholic fatty liver disease
Published Online: Feb 04 2020
DOI: 10.1002/wsbm.1480
Complex gene regulatory networks underlie liver homeostasis. NAFLD development is characterized by changes gene expression, which reflect pervasive rewiring of liver transcriptional networks by integration of aberrant intrinsic and extrinsic cues.
Abstract Full article on Wiley Online Library:   HTML | PDF
How personalized heart modeling can help treatment of lethal arrhythmias: A focus on ventricular tachycardia ablation strategies in post‐infarction patients
Published Online: Jan 09 2020
DOI: 10.1002/wsbm.1477
Noninvasively predicting the targets of ablation of lethal arrhythmia, ventricular tachycardia (VT), using patient‐specific models in ischemic cardiomyopathy patients.
Abstract Full article on Wiley Online Library:   HTML | PDF
Growth control in the Drosophila wing disk
Published Online: Jan 09 2020
DOI: 10.1002/wsbm.1478
Growth control in a wing disk is the result of outputs from a complex signal transduction network like that shown above.
Abstract Full article on Wiley Online Library:   HTML | PDF
Lactate: Fueling the fire starter
Published Online: Dec 16 2019
DOI: 10.1002/wsbm.1474
Immune cells ‘sense’ high concentration of lactate which accumulates at the site of inflammation or tumor as result of accelerated metabolism of immune, stromal, or cancer cells.
Abstract Full article on Wiley Online Library:   HTML | PDF
Applications of stable isotope‐based metabolomics and fluxomics toward synthetic biology of cyanobacteria
Published Online: Dec 09 2019
DOI: 10.1002/wsbm.1472
Overview of metabolomics and fluxomics workflows applied to cyanobacteria.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Articles

Intracellular signaling dynamics and their role in coordinating tissue repair
Published Online: Feb 08 2020
DOI: 10.1002/wsbm.1479
Intracellular signaling dynamics are critical for detecting injury, encoding information about an injury, and coordinating a tissue‐wide repair response. These signaling dynamics can now be spatiotemporally quantified and controlled using new technologies, linking them directly to the repair processes they coordinate.
Abstract Full article on Wiley Online Library:   HTML | PDF
The evolution of genomic imprinting: Epigenetic control of mammary gland development and postnatal resource control
Published Online: Dec 26 2019
DOI: 10.1002/wsbm.1476
A systematic review of imprinted gene expression in the mammary gland suggests that imprinting could be associated with mammary gland development and postnatal resource allocation, with implications for the evolution of imprinting and healthy development of mammalian offspring.
Abstract Full article on Wiley Online Library:   HTML | PDF

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