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WIREs Syst Biol Med
Impact Factor: 4.192
Wiley Interdisciplinary Reviews:
WIREs Systems Biology and Medicine
Volume 12 Issue 5 (September 2020)
Page 0 - 0

Advanced Reviews

Aspirin and the chemoprevention of cancers: A mathematical and evolutionary dynamics perspective
Published Online: Mar 12 2020
DOI: 10.1002/wsbm.1487
Mathematical modeling and methods of evolutionary biology help understand the role of aspirin in cancer prevention.
Abstract Full article on Wiley Online Library:   HTML | PDF
The immunologic Warburg effect: Evidence and therapeutic opportunities in autoimmunity
Published Online: Feb 27 2020
DOI: 10.1002/wsbm.1486
The immunologic Warburg effect represents a potential target for treating autoimmune diseases, through both pharmacologic and dietary strategies. The mechanisms explaining the requirement for aerobic glycolysis in immune activation remain only partially understood.
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Article

Regulating cellular cyclic adenosine monophosphate: “Sources,” “sinks,” and now, “tunable valves”
Published Online: Apr 23 2020
DOI: 10.1002/wsbm.1490
Schematic displays information transmission in cells, where the data that is carried forward is cyclic AMP flux. Ligand‐activated receptors serve as ‘sources’ of such data, whereas phosphodiesterases serve as ‘sinks’ for the same. In this work, the authors describe the presence of a tunable valve (channel) that is poised between the ‘sources’ and the ‘sinks’. Comprised of Guanine nucleotide Exchange Modulators (GEM) and the trimeric GTPase system,this valve adds emergent features that control cAMP flux in cells.
Abstract Full article on Wiley Online Library:   HTML | PDF

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