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WIREs Syst Biol Med
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Wiley Interdisciplinary Reviews:
WIREs Systems Biology and Medicine
Volume 12 Issue 6 (November 2020)
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Advanced Reviews

Mammalian cell and tissue imaging using Raman and coherent Raman microscopy
Published Online: Jul 19 2020
DOI: 10.1002/wsbm.1501
Direct imaging of metabolism in cells or multicellular organisms is important for understanding many biological processes. Coherent Raman scattering such as coherent anti‐Stokes Raman scattering and stimulated Raman scattering, has emerged as a powerful platform for cell and tissue imaging due to its high selectivity, sensitivity, and imaging speed. We review the advances and applications of Raman microscopy for a better understanding of cell metabolic dynamics.
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Molecular networks in Network Medicine: Development and applications
Published Online: Apr 19 2020
DOI: 10.1002/wsbm.1489
The Visual Analytics cycle applied to Network Medicine. Data from different domains (e.g., cellular, molecular, and genetic networks) are input to two different processes, Visual Data Exploration which exploits visualization paradigms (Node‐Edge, Matrix, Chords, etc.) to represent these data and classic Automated Data Analysis through different approaches (machine learning, network analysis algorithms, etc.). These two processes are interconnected, allowing an analyst to steer algorithms by interacting with the visual representation of results. The whole process generates new insights (e.g., relationships among networks) used as a feedback loop for new cycles of analysis.
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Focus Article

Computational models to explore the complexity of the epithelial to mesenchymal transition in cancer
Published Online: Mar 24 2020
DOI: 10.1002/wsbm.1488
The combination of experimental and computational analysis is advancing the complete characterization of complex biological processes such as the epithelial to mesenchymal transition. Computational studies can be performed both in terms of signal transduction networks, that describe gene expression regulation and single cells or population dynamics, and multiscale models that integrate cell–cell and cell–environment interactions, besides modeling migration patterns.
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