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Wiley Interdisciplinary Reviews:
WIREs Systems Biology and Medicine
Volume 9 Issue 2 (March 2017)
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Cover Image

Cover Image, Volume 9, Issue 2
Yaroslav I. Molkov, Jonathan E. Rubin, Ilya A. Rybak, Jeffrey C. Smith
Published Online: Feb 17 2017
DOI: 10.1002/wsbm.1384
The cover image, by Ilya A. Rybak et al., is based on Advanced Review Computational models of the neural control of breathing, DOI: 10.1002/wsbm.1371.
Abstract Full article on Wiley Online Library:   HTML | PDF

Overview

Cancer and inflammation
Lance L. Munn
Published Online: Dec 12 2016
DOI: 10.1002/wsbm.1370
Inflammation can contribute to cancer progression, and conversely, cancer can induce inflammatory processes. Understanding how inflammatory cells and cytokines support tumor growth and suppress anti‐cancer immunity will help identify new strategies for preventing or treating cancer
Abstract Full article on Wiley Online Library:   HTML | PDF

Advanced Reviews

Insights into nuclear dynamics using live‐cell imaging approaches
Rachel B. Bigley, Alexander Y. Payumo, Jeffrey M. Alexander, Guo N. Huang
Published Online: Jan 12 2017
DOI: 10.1002/wsbm.1372
DNA Interactions Within the Nucleus.
Abstract Full article on Wiley Online Library:   HTML | PDF
Traditional and novel tools to probe the mitochondrial metabolism in health and disease
Yanfei Zhang, José L. Avalos
Published Online: Jan 09 2017
DOI: 10.1002/wsbm.1373
Tools to probe the mitochondrial metabolism. We owe our current understanding of mitochondrial metabolism to a diverse set of tools that have been developed in the last half century, ranging from traditional tools, such as respirometry, dyes, and pharmacological agents, to more modern tools such as biosensors, metabolic flux analysis (MFA), and trans‐omics technologies.
Abstract Full article on Wiley Online Library:   HTML | PDF
Computational models of the neural control of breathing
Yaroslav I. Molkov, Jonathan E. Rubin, Ilya A. Rybak, Jeffrey C. Smith
Published Online: Dec 23 2016
DOI: 10.1002/wsbm.1371
Abstract Full article on Wiley Online Library:   HTML | PDF

Focus Articles

Quantitative approaches for investigating the spatial context of gene expression
Je H. Lee
Published Online: Dec 21 2016
DOI: 10.1002/wsbm.1369
Studying functional evolution requires co‐localization of the phenotypic variation, the selection pressure, and genetic taxonomy with single‐cell resolution in situ.
Abstract Full article on Wiley Online Library:   HTML | PDF
Toward modeling locomotion using electromyography‐informed 3D models: application to cerebral palsy
M. Sartori, J. W. Fernandez, L. Modenese, C. P. Carty, L. A. Barber, K. Oberhofer, J. Zhang, G. G. Handsfield, N. S. Stott, T. F. Besier, D. Farina, D. G. Lloyd
Published Online: Dec 21 2016
DOI: 10.1002/wsbm.1368
Modeling pipeline from neural function to rigid body mechanics, continuum muscle and model prediction.
Abstract Full article on Wiley Online Library:   HTML | PDF

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