• Targeting epidermal growth factor receptor co‐dependent signaling pathways in glioblastoma
• Recent lab‐on‐chip developments for novel drug discovery

• Theory of cell fate
• Stability analysis in spatial modeling of cell signaling

• Thermoregulation: A journey from physiology to computational models and the intensive care unit
• Decoding pluripotency: Genetic screens to interrogate the acquisition, maintenance, and exit of pluripotency

• Circadian rhythms and the HPA axis: A systems view
• Tools for computational analysis of moving boundary problems in cellular mechanobiology

• Regulating cellular cyclic adenosine monophosphate: “Sources,” “sinks,” and now, “tunable valves”
• Computational models to explore the complexity of the epithelial to mesenchymal transition in cancer

• Drug discovery and the maze of biological complexity: an editorial essay
• Pathways, networks, and systems medicine—the meeting place of the Aegean and the mind

Cancer and inflammation
Overview
Lance L. Munn

Immunity to CRISPR Cas9 and Cas12a therapeutics
Focus Article
Wei Leong Chew

Computational models of the neural control of breathing
Advanced Review
Yaroslav I. Molkov,Jonathan E. Rubin,Ilya A. Rybak,Jeffrey C. Smith

PharmGKB: A worldwide resource for pharmacogenomic information
Advanced Review
Julia M. Barbarino,Michelle Whirl‐Carrillo,Russ B. Altman,Teri E. Klein